OS Compatibility Checker

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macOS 10.13 High Sierra
Yes

You may be required to manually allow the driver to load, please see this article

macOS 10.12 Sierra
Yes
Mac 10.11
Yes
Mac 10.10
Yes
Mac 10.9
Yes
Mac 10.8
Yes
Mac 10.7
Yes
Mac 10.6
Yes
Mac 10.5
Yes

Please install Saffire Mix Control 2.4

Mac 10.4
Yes
Windows 10 AU (Redstone)
Yes
Windows Vista64
No
Windows Vista
No
Windows XP64
No
Windows XP
Yes

Service Pack 2 and above only.